PYP results β quote from ASNC Practice Points, cited in 2022
βWhile grade 2-3 or H/CL >1.5 uptake is strongly suggestive of TTR amyloidosis, any degree of 99mTc-PYP uptake can also be seen in AL amyloidosis, and as such a complete evaluation is warranted to exclude this diagnosis.β
I believe you need to rule out AL amyloidosis with blood and urine tests first . But yes, a PYP scan can determine if you have it or not.