I have always said that patients are the best educators!
Sheldon proves my point! Thank you Sheldon!

Anyone who believes that any symptoms of amyloidosis are relieved by Vyndamax is quite seriously wrong. It does not change any aspect of your clinical status. It literally just slows down the progress of your disease. Ask any medical researchers or amyloidosis specialists. Any doctors suggesting that symptoms are relieved is absolutely wrong. I've spent many hours over many months reading all of the studies. My conclusion is correct.

Knockdown drugs also called Silencer drugs, such as Amvuttra and Patisiran or Eplontersen, are more valuable treatments since they greatly reduce production of transthyretin in your liver.

Acoramidis may prove to be a superior stabilizer drug therapy than Vyndamax/Tafamidis. Acoramidis seems to go deeper into the TTR protein to better stabilize the bonds between the Hydrogen atoms and the 4 identical TTR proteins. That maintains he tetrameric (it means 4) TTR protein structure. It then doesn't break apart or misfold into amyloid fibrils that are monomers. Those end up destroying tissues in our bodies. They are toxic.

The already deposited amyloid fibrils are toxic. They eventually do destroy tissues wherever they are deposited. Tafadamis only works to a very, very limited degree to stabilize newly liver produced TTR. It is a temporary respite, not that long lasting. Read the studies! If you are diagnosed early then you have better survival odds.

I have talked with Sheldon and feel better after. He knows more than most Drs.about this disease!! Joe

One of my favorite quotations. I use it all the time to combat magical thinking…