Wild-type amyloidosis, previously known as senile systemic amyloidosis, typically affects men over 65. It occurs when the TTR protein, though normal, produces amyloid deposits in the heart for unknown reasons.
Diagnosis involves several tests that may include
- Blood and urine tests to detect amyloid protein
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Wild-type amyloidosis, previously known as senile systemic amyloidosis, typically affects men over 65. It occurs when the TTR protein, though normal, produces amyloid deposits in the heart for unknown reasons.
Diagnosis involves several tests that may include:
- Blood and urine tests to detect amyloid protein
- Echocardiogram to assess heart function
- Electrocardiogram for electrical signals
- Cardiac MRI for detailed heart imaging
- Heart biopsy to confirm amyloid deposits Common symptoms may not appear until advanced stages and can include:
- Shortness of breath (even during light activity or rest)
- Heart palpitations
- Swelling in feet, ankles, legs, and abdomen
- Persistent fatigue
- Enlarged neck veins
While there's no cure currently, newer treatments have emerged in the past decade that can help slow disease progression and improve survival rates. Treatment focuses on slowing amyloid production and addressing heart damage.
June 23, 2025
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