Systemic amyloidosis occurs when abnormal proteins, called amyloid, build up in multiple organs and tissues throughout your body. This makes it harder for those organs to work properly.
Unlike localized amyloidosis (where deposits appear in just one area), systemic amyloidosis affects many parts of the body at once. The Show Full Answer
Systemic amyloidosis occurs when abnormal proteins, called amyloid, build up in multiple organs and tissues throughout your body. This makes it harder for those organs to work properly.
Unlike localized amyloidosis (where deposits appear in just one area), systemic amyloidosis affects many parts of the body at once. The amyloid deposits can appear in different locations and cause a wide range of symptoms.
The main types of systemic amyloidosis include:
* AL amyloidosis (amyloid light-chain) - The most common type, often affecting the heart and kidneys
* AA amyloidosis (reactive amyloidosis) - Usually triggered by chronic inflammation, typically affecting kidneys, liver, and digestive tract
* Hereditary ATTR amyloidosis - Passed down through families due to a genetic mutation
* Wild-type ATTR amyloidosis - Develops from age-related changes in the TTR protein
Each type is named for the specific protein that forms the amyloid deposits. Commonly affected organs include the heart, kidneys, liver, nervous system, and digestive tract.
Early diagnosis is important because the sooner treatment begins, the better the chance of preventing long-term organ damage. Your healthcare team will determine which type you have to choose the right treatment approach.
April 14
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