Are you looking for information about polyneuropathy (PN) and loss of strength in wild-type ATTR (ATTR-wt) amyloidosis?
While ATTR-wt more commonly affects the heart, it can also involve the peripheral nervous system, leading to nerve-related symptoms including muscle weakness and loss of strength.
Amyloid deposits can Show Full Answer
Are you looking for information about polyneuropathy (PN) and loss of strength in wild-type ATTR (ATTR-wt) amyloidosis?
While ATTR-wt more commonly affects the heart, it can also involve the peripheral nervous system, leading to nerve-related symptoms including muscle weakness and loss of strength.
Amyloid deposits can build up around nerve fibers, disrupting the signals nerves send to muscles. This can affect three types of nerves:
- Sensory nerves — causing pain, tingling, numbness, or burning
- Motor nerves — leading to muscle weakness, balance problems, and difficulty walking
- Autonomic nerves — affecting automatic functions like blood pressure and digestion As one MyAmyloidosisTeam member shared: *"I'm in pain and off balance when I am walking."*
There are ways to help manage strength loss and PN symptoms:
- Low-impact exercise like swimming, water aerobics, or a recumbent bike can help build muscle and improve mobility
- Physical therapy can provide a safe, personalized exercise plan
- Occupational therapy can help with everyday tasks
- Pain management should always be discussed with your healthcare provider
It's important never to push through pain, and to let your doctor know if symptoms change. A referral to a neurologist who specializes in amyloidosis is worth discussing with your care team.
May 11
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