Amyloidosis can affect the skin in several ways, depending on the type. When amyloid proteins build up in or near the skin, they can cause a range of visible and uncomfortable symptoms.
Common skin symptoms include:
- Purpura – purple, red, or dark-colored spots or patches, often around the eyes
- Waxy bumps – small Show Full Answer
Amyloidosis can affect the skin in several ways, depending on the type. When amyloid proteins build up in or near the skin, they can cause a range of visible and uncomfortable symptoms.
Common skin symptoms include:
- Purpura – purple, red, or dark-colored spots or patches, often around the eyes
- Waxy bumps – small raised areas near the eyelids, neck, or groin
- Thickened or scaly skin – patches that may also be itchy
- Blisters filled with blood
- Brittle or discolored nails
- Hair loss
- Swelling or bruising around the eyes When amyloidosis primarily affects the skin, it's called primary localized cutaneous amyloidosis (PLCA). There are a few types:
- Lichen amyloidosis – very itchy, scaly rash, often on the legs and arms
- Macular amyloidosis – flat, itchy brown or gray patches, usually on the upper back or chest
- Nodular amyloidosis – firm, raised bumps on the face, limbs, or torso
One MyAmyloidosisTeam member described it as "thick white stuff built up under the skin," while another said their skin looked and felt like a sunburn.
The good news is that skin-only amyloidosis doesn't spread to internal organs. However, if amyloidosis is systemic, skin symptoms can still appear alongside other organ involvement. Always keep your care team updated on any skin changes.
August 11
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