MyAmyloidosisTeam

It's completely understandable to feel frustrated when it seems like treatment options are limited. The good news is that foot and nerve symptoms in wild-type ATTR amyloidosis (ATTRwt) are recognized and can be managed, even if the approach differs from hereditary forms.

You're right that some targeted therapies were Show Full Answer

It's completely understandable to feel frustrated when it seems like treatment options are limited. The good news is that foot and nerve symptoms in wild-type ATTR amyloidosis (ATTRwt) are recognized and can be managed, even if the approach differs from hereditary forms.

You're right that some targeted therapies were initially developed with hereditary amyloidosis in mind. However, treatment options for ATTRwt have expanded and continue to grow. Medications like tafamidis are approved for ATTRwt, primarily for heart-related symptoms, but managing nerve symptoms is also part of overall care.

For foot-related symptoms specifically, supportive care can make a real difference:

- Pain management — your doctor can recommend medications to help with nerve pain
- Physical therapy — to help with weakness, balance, and walking difficulties
- Occupational therapy — to help maintain independence in daily tasks
- Fall prevention — removing home hazards and using handrails
- Footwear adjustments — to manage sensitivity and discomfort

Numbness also raises the risk of unnoticed cuts or blisters, so regular foot checks are important.

The key is working closely with your care team to address each symptom. Asking for referrals to specialists like a neurologist, physical therapist, or pain management doctor can open up more options.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

Amyloidosis and the Feet: Numbness, Swelling, Pain, and 5 Other Symptoms