Great question! Both are types of amyloidosis, but they differ in the protein involved, who they affect, and how they're treated.
AL Amyloidosis
- Caused by abnormal light chain proteins produced by plasma cells in the bone marrow
- Can affect multiple organs, including the heart, kidneys, liver, and nerves
- Not inherited — Show Full Answer
Great question! Both are types of amyloidosis, but they differ in the protein involved, who they affect, and how they're treated.
AL Amyloidosis
- Caused by abnormal light chain proteins produced by plasma cells in the bone marrow
- Can affect multiple organs, including the heart, kidneys, liver, and nerves
- Not inherited — it's not passed down through families
- Tends to progress more quickly if untreated ATTR-CM (Transthyretin Amyloid Cardiomyopathy)
- Caused by a protein called transthyretin (TTR), made in the liver
- Primarily affects the heart
- Comes in two forms:
- Hereditary (hATTR) — caused by a gene mutation passed down in families
- Wild-type (ATTRwt) — not inherited; linked to aging, most common in men over 70
- Generally has a slower progression than AL amyloidosis The treatments for each type are also different, so getting an accurate diagnosis is really important. Talking to a specialist who focuses on amyloidosis can help make sure the right type is identified and the best treatment plan is put in place.
October 15
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