Thanks for comment on ankle pain. Will talk to Amyloidosis doctor at next appointment.

Quite possible, it may be a deposition of amyloid fibrils around the nerve that affects your ankle. It certainly should be considered as a cause of your pain.

Hi, I have been taking Allopurinol for 20 years now for kidney stones/gout. The pain near my ankle is more recent and affects the nerve that passes right near the ankle bone. Since no one can figure out why I have that pain, I'm beginning to think is has something to do with ATTRwt..

I have been on vyndamax for four months now and have lost a lot of weight. I also have suffered 4-5 gout flare ups in both feet….very painfull and lasts for 3-4days. Colchicine prescription seems to help clear up the gout.

Thanks for sharing your issues with the ankle problem. I have a feeling these ATTR proteins can reach any part of the body. I had a triple spinal fusion a few years ago which I think may have been due to ATTRwt. Hard to tell but these things keep cropping up.