MyAmyloidosisTeam

Wild-type ATTR amyloidosis (ATTRwt) primarily affects the heart, but symptoms and progression can vary significantly between individuals. In early stages, people may have mild symptoms or no symptoms at all. The condition typically doesn't appear until after age 65, when the normal TTR protein becomes less stable and begins Show Full Answer

Wild-type ATTR amyloidosis (ATTRwt) primarily affects the heart, but symptoms and progression can vary significantly between individuals. In early stages, people may have mild symptoms or no symptoms at all. The condition typically doesn't appear until after age 65, when the normal TTR protein becomes less stable and begins to misfold. While cardiac involvement is very common with wild-type ATTR, the progression rate varies. Some people have good outcomes - one study found that 85% of people survived their first year after diagnosis. The condition can be monitored using biomarkers that measure heart and kidney function, which helps doctors track progression and predict outcomes.

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