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A MyAmyloidosisTeam Member asked a question ๐Ÿ’ญ
Jonesborough, TN
July 27, 2025
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Answer Summary

Members shared their experiences transitioning from Vyndamax to Attruby for ATTR amyloidosis, with most reporting no side effects beyond the... Read more

Members shared their experiences transitioning from Vyndamax to Attruby for ATTR amyloidosis, with most reporting no side effects beyond the need to take it twice daily instead of once, and some noting improvements in nerve symptoms, walking ability, and overall numbers after several months. Several members discussed the clinical reasoning behind the switch, including Attruby's reported 90% stabilization rate compared to 50-60% for other medications, though some doctors remain cautious due to the lack of direct comparison studies and potential bias toward Vyndamax from Pfizer-funded research. A recurring theme was cautious optimism mixed with determination, as members balanced hope for better outcomes with the reality of living with a progressive disease, many staying active and refusing to give up while awaiting potential future treatments.

A MyAmyloidosisTeam Member

Food for thought....I am on VYNDAMAX, I am going to see the heart Dr. In October and I will ask him about any other meds I can take. I have WT ATTRCM stage 2 as told stage 2 is 44 months to live. Average life span after being diagnosed is 7.5 years. I am not ready to give up this life, just wish it were a better life. I always have a lot of question for my Dr. I read everything I can about this death sentence that we have. I try to be I formed.
Hope YOU have a good day.

And I want to thank everyone for the hugs

August 20, 2025
A MyAmyloidosisTeam Member

Great question to ask all of the doctors who have funding or had funding for studies from Pfizer. There is a clear bias in favor of Vyndamax. The claim is that "they don't know which has greater efficacy". The cardiologists base it on the current lack of any Attruby vs Vyndamax one-on-one direct comparison.

July 30, 2025 (edited)
A MyAmyloidosisTeam Member

Hi All, I was on Vyndaqel and switched to Attruby on 01/01/2026, I am also on Amvuttra and am due for my second shot next week. I just received orders for labs so should have some clinical ideas in a few weeks. I have ATTR-CM and have no noticeable side effects from the meds. My main complaints are shortness of breath and increased arthritis pain. Iโ€™m 85 and still cranking along.๐Ÿ˜‹

January 29
A MyAmyloidosisTeam Member

Have been taking attruby since January. I knew it was a new medicine approved last year. Was told it probably would show some improvement in Amyloidosis problems. After 8 months, I am not having nerve shocks and numbness seems to be improving.

August 19, 2025
A MyAmyloidosisTeam Member

On Attruby, going to add Amvuttra in coming months.
Going forward taking both

Dennis DB

August 6, 2025

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