AL amyloidosis can significantly impact kidney function when abnormal proteins form sticky clumps (amyloid fibrils) that get deposited in the kidneys. About two-thirds of people with AL amyloidosis experience kidney involvement. These deposits interfere with the kidney's normal filtering process.
Common signs and symptoms Show Full Answer
AL amyloidosis can significantly impact kidney function when abnormal proteins form sticky clumps (amyloid fibrils) that get deposited in the kidneys. About two-thirds of people with AL amyloidosis experience kidney involvement. These deposits interfere with the kidney's normal filtering process.
Common signs and symptoms include:
• Changes in urination frequency
• Needing to urinate at night
• Bubbles in the urine
• Swelling in legs or abdomen When amyloid deposits build up, they can cause nephrotic syndrome, where proteins leak into the urine. This condition can be detected through blood and urine tests, which may show:
• Excess albumin protein in urine
• Low albumin levels in blood
• High levels of fats and cholesterol in blood
If left untreated, these deposits can eventually lead to kidney failure, requiring dialysis. Treatment options like chemotherapy followed by stem cell transplants may help improve kidney function in some cases.
August 31, 2025
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