Doctors determine your amyloidosis stage by measuring specific biomarkers in your blood that indicate how well your organs are functioning and the extent of damage. The three key biomarkers they look at are:
• NT-proBNP - Shows how well your heart is working
• Cardiac troponin T (cTnT) - Indicates heart cell damage
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Doctors determine your amyloidosis stage by measuring specific biomarkers in your blood that indicate how well your organs are functioning and the extent of damage. The three key biomarkers they look at are:
• NT-proBNP - Shows how well your heart is working
• Cardiac troponin T (cTnT) - Indicates heart cell damage
• Difference between involved/uninvolved free light chains (dFLC) - Measures abnormal protein buildup Using the Mayo Clinic staging system, your stage is determined by how many of these biomarkers are elevated:
• Stage 1: All biomarkers normal
• Stage 2: One biomarker elevated
• Stage 3: Two biomarkers elevated
• Stage 4: All three biomarkers elevated
Your healthcare team will monitor these levels over time to track disease progression and adjust treatment as needed. Some doctors may use modified versions of this system or focus on different organs depending on how amyloidosis affects you specifically.
October 16, 2025