How does wild-type ATTR amyloidosis affect the eyes and facial appearance around the eyes?
Wild-type ATTR amyloidosis (wtATTR) can cause several eye-related changes as amyloid proteins build up. Here are the main impacts:
Common eye symptoms include
* Floaters (dark spots or strings in your vision)
* Changes in pupil Show Full Answer
How does wild-type ATTR amyloidosis affect the eyes and facial appearance around the eyes?
Wild-type ATTR amyloidosis (wtATTR) can cause several eye-related changes as amyloid proteins build up. Here are the main impacts:
Common eye symptoms include:
* Floaters (dark spots or strings in your vision)
* Changes in pupil appearance
* Enlarged or abnormal blood vessels on the conjunctiva (the clear outer layer of the eye)
* Glaucoma (increased pressure inside the eye)
Specific eye conditions that may develop:
* Conjunctival amyloidosis - appears as small, yellow, waxy masses on the eye
* Corneal issues - can cause vision problems and a hazy appearance
* Loss of corneal sensitivity, which is important for blinking and eye protection
While wtATTR primarily affects the heart in older adults, these eye changes can occur as the disease progresses. The symptoms often appear later in the disease course.
If you notice any changes in your vision or eye appearance, let your ophthalmologist know right away. Early detection and treatment can help manage symptoms and slow disease progression.
November 27, 2025
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