No. 50/50 chance for each child. If child is negative, it cannot be inherited from that child.
March 26
Does hereditary amyloidosis skip generations?
Hereditary amyloidosis doesn't skip generations in the traditional sense. If you have a parent with hereditary amyloidosis, you have a 50 percent chance of inheriting the gene mutation. However, having the gene doesn't guarantee you'll develop symptoms.
This is an important Show Full Answer
Does hereditary amyloidosis skip generations?
Hereditary amyloidosis doesn't skip generations in the traditional sense. If you have a parent with hereditary amyloidosis, you have a 50 percent chance of inheriting the gene mutation. However, having the gene doesn't guarantee you'll develop symptoms.
This is an important distinction. The gene itself is passed directly from parent to child, but the disease may not show up in every generation because:
- Not everyone who inherits the mutation develops symptoms
- Symptoms may start at different ages
- Some people with the gene may never become symptomatic
Given your family history with cardiac issues on both sides and your uncle's early death from cardiomyopathy, it's worth discussing genetic testing with your doctor. They can help determine if hereditary ATTR amyloidosis or another genetic cardiac condition runs in your family.
If hereditary amyloidosis is confirmed in your family, genetic counseling can help you understand your personal risk and whether testing makes sense for you.
March 8
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