The drugs used to treat amyloidosis depend on the type you have. Here's a breakdown by category:
Chemotherapy drugs (mainly for AL amyloidosis):
- Melphalan (Alkeran or Evomela)
- Cyclophosphamide (Cytoxan)
- Bendamustine (Treanda)
Steroids (used alongside chemotherapy):
- Dexamethasone
- Prednisone
Proteasome Show Full Answer
The drugs used to treat amyloidosis depend on the type you have. Here's a breakdown by category:
Chemotherapy drugs (mainly for AL amyloidosis):
- Melphalan (Alkeran or Evomela)
- Cyclophosphamide (Cytoxan)
- Bendamustine (Treanda)
Steroids (used alongside chemotherapy):
- Dexamethasone
- Prednisone
Proteasome inhibitors:
- Bortezomib (Velcade)
- Carfilzomib (Kyprolis)
- Ixazomib (Ninlaro)
Monoclonal antibodies (immunotherapy):
- Daratumumab (Darzalex)
- Daratumumab + hyaluronidase (Darzalex Faspro)
- Elotuzumab (Empliciti)
Immunomodulatory drugs (IMiDs):
- Thalidomide (Thalomid)
- Lenalidomide (Revlimid)
- Pomalidomide (Pomalyst)
For ATTR amyloidosis specifically:
- Tafamidis (Vyndamax or Vyndaqel) — FDA-approved for amyloidosis-related heart disease
- Diflunisal (Dolobid) — may help with hereditary ATTR amyloidosis Many of these medications are used in combination. For example, a common treatment plan for newly diagnosed AL amyloidosis includes bortezomib, cyclophosphamide, daratumumab, and dexamethasone together.
It's worth noting that many of these drugs are used "off-label," meaning they were originally approved for other conditions but have shown effectiveness for amyloidosis in clinical trials.
Always work closely with your care team to find the right combination for your specific type and situation — there's no one-size-fits-all approach here!
April 25
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