It can take up to 6-9 mo after starting dosing to kick in
July 17
Feeling worse after starting Vyndamax (tafamidis) can be frustrating, especially when you're hoping for improvement. It's actually something others with amyloidosis have experienced too — one MyAmyloidosisTeam member shared that "some days are OK, other days I can't get out of my chair," and another said treatment "wipes me Show Full Answer
Feeling worse after starting Vyndamax (tafamidis) can be frustrating, especially when you're hoping for improvement. It's actually something others with amyloidosis have experienced too — one MyAmyloidosisTeam member shared that "some days are OK, other days I can't get out of my chair," and another said treatment "wipes me out for two weeks."
There are a few reasons why you might feel worse even while on treatment: - The disease may still be progressing — Vyndamax works to slow progression, but it may not reverse symptoms already present
- Fatigue and low energy are common with amyloidosis itself, driven by heart strain, nerve involvement, or sleep disruption
- Treatment side effects can affect energy, mobility, and overall function
- Amyloid buildup may continue affecting organs even during treatment in the early stages
The important thing is to bring specific details to your doctor — what time of day you feel worst, what activities trigger it, and what (if anything) helps. Two months in is a good checkpoint to have that honest conversation with your care team about whether adjustments are needed.
July 17
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