Carpal tunnel syndrome and wrist pain are most commonly linked to transthyretin amyloidosis (ATTR), particularly wild-type ATTR amyloidosis. It can also occur with AL amyloidosis (light-chain amyloidosis).
With ATTR, amyloid deposits build up around the median nerve in the wrist, compressing it and causing the classic Show Full Answer
Carpal tunnel syndrome and wrist pain are most commonly linked to transthyretin amyloidosis (ATTR), particularly wild-type ATTR amyloidosis. It can also occur with AL amyloidosis (light-chain amyloidosis).
With ATTR, amyloid deposits build up around the median nerve in the wrist, compressing it and causing the classic carpal tunnel symptoms. A key pattern to watch for is symptoms appearing in both wrists at the same time — this bilateral presentation is strongly associated with amyloidosis. Carpal tunnel symptoms can actually show up before heart-related symptoms in ATTR, making it a potentially important early warning sign. Some MyAmyloidosisTeam members have even received their amyloidosis diagnosis through a carpal tunnel biopsy.
Common carpal tunnel symptoms to be aware of include:
- Numbness or tingling in the hands
- Weak grip or frequently dropping objects
- Pain or an electric shock-like sensation in the wrist or hand
- Symptoms that may start only in the morning but become constant over time
It's worth discussing these symptoms with a doctor, especially if both wrists are affected.
August 1
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