Staging wild-type ATTR-CM typically involves a combination of tests that help doctors understand how far the disease has progressed. Here's a summary of the key tests commonly used:
Heart Function Tests
- Echocardiogram β Uses sound waves to assess heart wall thickness, stiffness, and pumping ability
- Cardiac MRI β Show Full Answer
Staging wild-type ATTR-CM typically involves a combination of tests that help doctors understand how far the disease has progressed. Here's a summary of the key tests commonly used:
Heart Function Tests:
- Echocardiogram β Uses sound waves to assess heart wall thickness, stiffness, and pumping ability
- Cardiac MRI β Provides detailed images of amyloid deposits in the heart muscle
- PYP (Pyrophosphate) scan β A nuclear imaging scan that can detect TTR amyloid deposits in the heart without a biopsy
Blood Tests:
- BNP or NT-proBNP β Markers that indicate how hard the heart is working; higher levels suggest more advanced disease
- Troponin β Elevated levels can signal heart muscle stress
Other Assessments:
- 6-minute walk test β Measures physical endurance and functional capacity
- ECG (electrocardiogram) β Detects arrhythmias like atrial fibrillation, which is common in ATTR-CM
These tests together help paint a full picture of disease severity. It's really important to work closely with a cardiologist or amyloidosis specialist, as early diagnosis and treatment can make a meaningful difference in slowing progression.
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