After my PYP scan I was started on Vyndamax.
October 13
I would suggest seeing another cardiologist ASAP. After my PYP SECT I was immediately placed on Vyndamax by my cardiologist.
October 13
That's a really valid question, and it's completely understandable to want clarity on what treatments are available after a PYP scan confirms cardiac amyloidosis.
The type of amyloidosis matters a lot when it comes to treatment options. There are FDA-approved disease-modifying therapies specifically for ATTR-CM Show Full Answer
That's a really valid question, and it's completely understandable to want clarity on what treatments are available after a PYP scan confirms cardiac amyloidosis.
The type of amyloidosis matters a lot when it comes to treatment options. There are FDA-approved disease-modifying therapies specifically for ATTR-CM (transthyretin amyloid cardiomyopathy) that can slow the progression of amyloid buildup in the heart. These include:
- TTR stabilizers like tafamidis (Vyndamax) and acoramidis (Attruby), which prevent the TTR protein from breaking apart and forming deposits
- TTR-silencing therapies like vutrisiran (Amvuttra), which reduce TTR production using RNA technology Diflunisal is sometimes used off-label as a TTR stabilizer, but it is not an FDA-approved therapy for cardiac amyloidosis the way tafamidis or acoramidis are.
If the PYP scan confirmed ATTR-CM specifically, it may be worth having a direct conversation with your doctor — or seeking a second opinion from an amyloidosis specialist — about whether FDA-approved therapies like tafamidis or acoramidis might be appropriate for your situation.
It's also worth noting that AL amyloidosis has a different treatment approach, focusing on chemotherapy and immunotherapy to target the abnormal cells producing the damaging proteins. So confirming your exact subtype is key to understanding all your options.
October 8
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