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My Kappa: Lambda Ratio has been slowly increasing over the past year. Now at 1.82 (ref range 0.26-1.65). My Oncologist suggested maybe making a change. The listed risks and protocol sure doesn’t sound very inviting.
Answer Summary
Members discussed transitioning to Tecvayli (Teclistamab) after Revlimid appeared to lose effectiveness, with one member who had undergone... Read more
Steve, I am always so happy that we have this group to bounce ideas off ... someone from the same tribe, who might appreciate what's going through the mind of one of our group. To generously share their experience is a gift to someone thirsty for such specific information. Mike
To be fair, I had little choice in the matter… Nevertheless, with proper care and monitoring, I wouldn’t be especially worried about Teclistamab. It’s essentially CAR-T in a box. Are there risks of severe CRS/ICANS? Sure, but manageable in the right environment. Sounds like you’ve have time to think it through, so that’s a plus. One other thing, I was youngish (52) and pretty healthy other than the heart failure (IIIa disease).
I had CAR-T (Cilta-cel) in 12/23. I was in the hospital for 15 days in an over-abundance of caution due to cardiac concerns. CRS was Grade 1 and lasted about a day. Easily managed with Tocilizumab. When remission ends, I’ll probably lobby for a transplant, but failing that, I’d have zero qualms about Teclistamab. Bear in mind, I’m in NYC, and can walk to Sloan Kettering on a good day…
Steve,
Sorry to hear your Kappa: Lambda ratio has been slowly increasing. I can't comment as I take nothing other than Gabapentin for peripheral neuropathy. Keep us updated with your changes. Mike
I take VYNDAMAX
TAFAMIDIS 61mg
El lun, 19 may 2025 a las 21:17, MyAmyloidosisTeam (<
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> Hi fernando,
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> One of your team members, Steve2, just asked a question. Do you have an
> answer for them?
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> "Anyone Using Tecvayli (Teclistamab)? It Looks Like Lenalidamine
> (Revlimid) Might Be No Longer Effective For Me."
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