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Real members of MyAmyloidosisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyAmyloidosisTeam Member asked a question 💭
Sacramento, CA

I’m having pain in my arms and hands enough to keep me awake at night. My hands are swelling. I’m also losing agility in my hands. Sometimes it aches in my shoulders too. It seems like I have so many symptoms:
A fib
Weight loss
Heart failure
Kidney failure
Pain in arms/hands
Fatigue
Loss of balance
Is anyone else experiencing this?

October 22, 2025
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Reactions
A MyAmyloidosisTeam Member

I had surgery on both for carpel tunnel several years ago.

October 22, 2025
A MyAmyloidosisTeam Member

I'm experiencing an identical problem with incessant pain in my hands and wrists, and I've been complaining about fatigue and loss of balance for years. I dropped 28 pounds in about six weeks - with no change of diet or routine.

October 24, 2025
MyAmyloidosisTeam

Many MyAmyloidosisTeam members experience similar symptoms with ATTR-CM. The pain and weakness in your hands could be related to carpal tunnel syndrome, which occurs in about half of people with ATTR-CM. This happens when TTR protein builds up in the carpal tunnel of your wrist, putting pressure on the nerves that control Show Full Answer

Many MyAmyloidosisTeam members experience similar symptoms with ATTR-CM. The pain and weakness in your hands could be related to carpal tunnel syndrome, which occurs in about half of people with ATTR-CM. This happens when TTR protein builds up in the carpal tunnel of your wrist, putting pressure on the nerves that control your hands.

Your symptoms of atrial fibrillation (AFib), fatigue, and heart failure are also common with ATTR-CM. Between 40-60% of people diagnosed with ATTR-CM have AFib, which can cause:
• Heart palpitations
• Shortness of breath
• Dizziness
• Fatigue
• Chest pain The fatigue you're experiencing is a common heart failure symptom in ATTR-CM, along with:
• Decreased appetite leading to weight loss
• Confusion or difficulty thinking
• Swelling in various parts of the body
• Balance issues

It's important to discuss these symptoms with your healthcare team, as they may need to adjust your treatment plan, especially since some heart failure medications may need special consideration with ATTR-CM.

October 22, 2025

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