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A MyAmyloidosisTeam Member asked a question 💭
Massachusetts
December 9, 2025
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Answer Summary

Members responded to the question about alternating constipation and diarrhea in amyloidosis, with many confirming this is a very common and... Read more

Members responded to the question about alternating constipation and diarrhea in amyloidosis, with many confirming this is a very common and frustrating experience, especially for those with GI tract involvement or autonomic neuropathy. Several members shared practical strategies including senna tablets, Miralax, lactulose, hot lemon water on an empty stomach, and senna-based herbal teas, with one member offering a thoughtful explanation about how amyloid-related gut dysfunction may cause a cycle of blockage followed by sudden diarrhea. A recurring theme was the emotional toll of unpredictable symptoms, including the heartbreak of having accidents in public, but members leaned on humor, faith, and each other to keep going.

A MyAmyloidosisTeam Member

I just do what I have to do. I’m not finished yet!

December 9, 2025
A MyAmyloidosisTeam Member

It is so frustrating for my husband and I'm sure all others with Amyloidois. I tell my husband Amyloidois is the gift that keeps on giving.

December 9, 2025
A MyAmyloidosisTeam Member

I think so. I found a video on YouTube (I think - it's been awhile) about a researcher at Stanford who talked about what he called pseudo-occlusions, where the gut behaves as if it is blocked. I'll have to find it again.
In my thoughts, that makes perfect sense as amyloidosis also causes autonomic neuropothy, interfering with proper bowel function. Food ends up sitting in the gut too long, the body continues to pull moisture out so your food, what's left of it, gets hard. As it eventually pushes through by the food behind it, and because not all of the entire length of your gut is affected. The dam breaks and now you have a spell of diarreah. Until you clean out a bit then the process starts over. You can take OTC senna tablets to keep you moving and also creating loose stool all the time, but at least not blocked up. I found that drinking a senna based herb tea is enough but a little gentler.

December 22, 2025 (edited)
A MyAmyloidosisTeam Member

I have amyloid in my GI tract so unfortunately I pretty much have diarrhea almost every day. I had a bad weekend but when Monday came along I started to feel better. Good days and bad days. 🤷🏻‍♀️

December 9, 2025
A MyAmyloidosisTeam Member

It is common and I have the same issue with Wild type.

December 9, 2025

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