What drug treatments are available for cardiac amyloidosis?
The medications used depend on whether you have AL or ATTR amyloidosis, as each type requires different approaches.
For AL Amyloidosis:
Treatment focuses on stopping abnormal plasma cells from producing harmful proteins. Options include:
* Daratumumab plus Show Full Answer
What drug treatments are available for cardiac amyloidosis?
The medications used depend on whether you have AL or ATTR amyloidosis, as each type requires different approaches.
For AL Amyloidosis:
Treatment focuses on stopping abnormal plasma cells from producing harmful proteins. Options include:
* Daratumumab plus hyaluronidase (Darzalex Faspro) - FDA-approved for newly diagnosed AL amyloidosis, used with other medications
* Chemotherapy drugs to target plasma cells
* Proteasome inhibitors to stop abnormal cell growth
* Immunomodulators to starve abnormal cells and boost your immune system
These are typically combined with steroids like dexamethasone for better results.
For ATTR Amyloidosis:
Several newer medications prevent amyloid buildup in the heart:
* Tafamidis (Vyndamax) and tafamidis meglumine (Vyndaqel) - approved in 2019
* Acoramidis (Attruby) - approved in 2024
* Vutrisiran (Amvuttra) - approved in 2025
For Heart Symptom Management:
Your doctor may also prescribe:
* Diuretics (water pills) to reduce fluid buildup
* Anti-arrhythmia medications for heart rhythm
* Blood thinners to prevent clots
Important note: Common heart failure drugs like ACE inhibitors, beta-blockers, and calcium channel blockers can be harmful with amyloidosis. Work with a specialist experienced in treating amyloidosis to ensure safe medication choices.
April 4
Join
Your Privacy Choices
