MyAmyloidosisTeam

That's an interesting and important combination of results. A negative flow cytometry means no abnormal clonal plasma cells were detected in the bone marrow — which might seem reassuring. However, a positive Congo red stain on the bone marrow biopsy confirms that amyloid protein deposits are present.

These two results are Show Full Answer

That's an interesting and important combination of results. A negative flow cytometry means no abnormal clonal plasma cells were detected in the bone marrow — which might seem reassuring. However, a positive Congo red stain on the bone marrow biopsy confirms that amyloid protein deposits are present.

These two results are not necessarily contradictory. Here's why: - Amyloid deposits can be present in the bone marrow even when clonal cells aren't detected by flow cytometry
- Flow cytometry may miss low levels of abnormal plasma cells
- The amyloid could be from a different type, such as ATTR (hereditary or wild-type) rather than AL amyloidosis
- Further testing is typically needed to identify exactly which protein is causing the deposits

The next step is usually additional typing tests to determine which kind of amyloidosis is present. This can include a serum free light-chain assay, immunofixation electrophoresis, or genetic testing for TTR mutations.

It's really important to work closely with a specialist — ideally one experienced in amyloidosis — to piece together the full picture and determine the right path forward.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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