When oral chemotherapy isn't working for AL amyloidosis, there are several other treatment paths worth exploring with your care team. The goal remains the same — stopping abnormal plasma cells from producing the harmful light-chain proteins that form amyloid deposits.
Here are some options that may be considered:
- Show Full Answer
When oral chemotherapy isn't working for AL amyloidosis, there are several other treatment paths worth exploring with your care team. The goal remains the same — stopping abnormal plasma cells from producing the harmful light-chain proteins that form amyloid deposits.
Here are some options that may be considered:
- Daratumumab + hyaluronidase (Darzalex Faspro) — the only FDA-approved treatment specifically for AL amyloidosis, given as an injection under the skin, usually combined with bortezomib, cyclophosphamide, and dexamethasone
- Proteasome inhibitors — such as Velcade (bortezomib), Kyprolis (carfilzomib), or Ninlaro (ixazomib), which target and destroy abnormal plasma cells
- Immunotherapy (monoclonal antibodies) — these use the immune system to help fight abnormal cell activity
- Autologous stem cell transplant — healthy stem cells are collected before high-dose chemotherapy, then reintroduced afterward to help rebuild; this can target the root cause more aggressively
- Organ transplant — if the heart or kidneys have been severely affected, this may be considered
- Clinical trials — research studies testing newer or emerging treatments may be an option worth asking your specialist about It's really important to work closely with a hematologist who specializes in amyloidosis, as treatment decisions depend on which organs are affected, overall health, and how the disease is progressing. Don't hesitate to ask about clinical trials — sometimes newer options are available that aren't yet widely known.
August 3
Join
Your Privacy Choices
