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Real members of MyAmyloidosisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
September 7
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A MyAmyloidosisTeam Member

I am very fortunate that my insurance covers both. I have Tri-Care for Life to go along with my medicare.

September 10
A MyAmyloidosisTeam Member

Sounds accurate. Very good your insurance covers both treatments.

September 7
MyAmyloidosisTeam

That's a great way to summarize how these two medications work — and your understanding is essentially correct!

Vyndamax (tafamidis) is a TTR stabilizer. It works by helping the transthyretin protein keep its correct shape, which prevents it from misfolding and clumping together into amyloid deposits in the heart.

Amvuttr Show Full Answer

That's a great way to summarize how these two medications work — and your understanding is essentially correct!

Vyndamax (tafamidis) is a TTR stabilizer. It works by helping the transthyretin protein keep its correct shape, which prevents it from misfolding and clumping together into amyloid deposits in the heart.

Amvuttra (vutrisiran) is a gene silencer. It works differently — it targets the liver and reduces how much transthyretin protein is produced in the first place, which helps prevent further amyloid buildup. So together, they're tackling the problem from two angles:

- Stabilizing the protein so it doesn't misfold
- Reducing how much of the protein is made

This combination approach is something your care team would have carefully considered for your specific situation. It's always worth checking in with them about how each medication is working for you and what monitoring is needed along the way.

September 7

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