What's causing those rough mornings with wild-type ATTR amyloidosis while on Acoramidis (Attruby)?
First, it's really encouraging that some mornings feel great — that's a sign the treatment may be doing its job. Wild-type ATTR is a slow-moving condition, and Attruby works by stabilizing the TTR protein to slow amyloid Show Full Answer
What's causing those rough mornings with wild-type ATTR amyloidosis while on Acoramidis (Attruby)?
First, it's really encouraging that some mornings feel great — that's a sign the treatment may be doing its job. Wild-type ATTR is a slow-moving condition, and Attruby works by stabilizing the TTR protein to slow amyloid buildup, but it can't reverse damage that's already occurred.
Those tough mornings could be related to several common symptoms of wild-type ATTR, including:
- Fatigue — one of the most reported symptoms
- Sudden drops in blood pressure when getting up (orthostatic hypotension)
- Digestive issues that can disrupt sleep or morning comfort
- Sleep disturbances linked to the condition itself A few things worth discussing with your care team:
- Timing of Attruby — ask whether taking it at a different time of day might help
- Morning blood pressure — checking it upon waking could reveal drops that explain the rough start
- Sleep quality — poor sleep can amplify daytime symptoms significantly
Tracking which mornings feel better versus worse (and any patterns like diet, activity, or sleep) can give your doctor really useful information. Don't hesitate to bring this up at your next appointment — symptom management is a big part of living well with this condition.
7 days ago
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