Switching from Vyndamax to Attruby (acoramidis) is a reasonable move — and your doctor isn't wrong about it being a strong option! Both are TTR stabilizers, meaning they work by preventing the transthyretin protein from breaking apart and forming amyloid deposits in the heart.
Here's what to know about taking Attruby:
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Switching from Vyndamax to Attruby (acoramidis) is a reasonable move — and your doctor isn't wrong about it being a strong option! Both are TTR stabilizers, meaning they work by preventing the transthyretin protein from breaking apart and forming amyloid deposits in the heart.
Here's what to know about taking Attruby:
- Taken as a tablet twice daily (vs. once daily for Vyndamax)
- Swallowed whole — no cutting, crushing, or chewing
- Can be taken with or without food In terms of side effects, most people tolerate it well, but here's what to watch for:
- Common: Diarrhea and upper abdominal pain
- Less common but worth monitoring: Changes in kidney function markers, which can show up in the first month but typically stabilize and are reversible if treatment stops
It's a good idea to flag any new digestive symptoms or changes in how you feel to your doctor early on, especially in that first month. Overall, Attruby is FDA-approved to reduce heart-related death and hospitalization in ATTR-CM, so you're still in good hands with this treatment. Keep up with your follow-up appointments so your doctor can monitor how your body is responding.
October 18
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