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My toes and feet have severe sharp pains, barely walk and toe is purple. Vascular doctor tells me. Blood flow is okay. I am not.amyloidosis?

A MyAmyloidosisTeam Member asked a question 💭
August 16, 2025
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A MyAmyloidosisTeam Member

Hmmmh supposedly amvuttra should help polyneuropathy.

August 22, 2025
A MyAmyloidosisTeam Member

Hi Shirley, of all the contributors I find my symptoms of confirmed ATTRwt closest to yours. Presently on Vyndaqel my problems started from echo scannings for a heart problem and progressed to where I am today. I go to bed around 11pm having taken pramipexole for my restless legs which then gets me off to sleep. Around 5am with pain in my lower legs I begin my day. On and off from then on, whilst on my feet, I will experience increasing pain from the knees to my feet, particularly in the right leg, until its intensity forces me to rest. This cycle persists all day. When standing, as weakness and pain peak I anticipate a fall and sit down. Recovery takes about 10-15 mins. literature recently received suggests I have Neuropathic Amyloidosis with ELAVIL (amitriptyline) as an additional treatment. To date my doctors do not accept the connection. Comments appreciated.

August 17, 2025
MyAmyloidosisTeam

Sharp foot pain and difficulty walking can be symptoms of amyloidosis. When amyloid proteins build up near nerves, they can cause various types of nerve pain - from sharp and stabbing to burning sensations. This nerve pain (amyloid neuropathy) often feels worse at night and can significantly impact walking ability. Common Show Full Answer

Sharp foot pain and difficulty walking can be symptoms of amyloidosis. When amyloid proteins build up near nerves, they can cause various types of nerve pain - from sharp and stabbing to burning sensations. This nerve pain (amyloid neuropathy) often feels worse at night and can significantly impact walking ability. Common foot-related symptoms of amyloidosis include:
• Burning or tingling sensations
• Sharp or dull nerve pain
• Difficulty walking or gait changes
• Numbness
• Increased sensitivity to touch
• Swelling in feet and ankles

Since your symptoms align with several amyloidosis indicators despite normal blood flow, it would be worthwhile to discuss these specific symptoms with your healthcare provider for proper evaluation and testing.

August 16, 2025

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