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Real members of MyAmyloidosisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Hi I have wild type ATTR. My prior health issues included trigger fingers, wrist tendon tear, biceps tendon tear, and bad back.

A MyAmyloidosisTeam Member asked a question 💭
Rancho Palos Verdes, CA

My question now is has anyone had any issues with a bad knee due to illial tibial band syndrome ( I have for many years back to time when I did a lot of running - sort of solved by increasing strength in my quadriceps.) But it has always been a bit tender. Now it seems pain and discomfort is back with a vengeance plus a lot of pain in my upper hamstring area. My concern is has the amyloid continued to build and weaken these areas of my right leg? Taking Vyndamax now for nearly two years… read more

November 7, 2025
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MyAmyloidosisTeam

Can amyloidosis affect muscles and tendons in your legs, and could it be causing your increased knee and hamstring pain along with nerve symptoms?

Yes, amyloidosis can affect tendons throughout the body. People with ATTR amyloidosis may experience tendon weakness when abnormal TTR protein builds up in the tendons. About 1 Show Full Answer

Can amyloidosis affect muscles and tendons in your legs, and could it be causing your increased knee and hamstring pain along with nerve symptoms?

Yes, amyloidosis can affect tendons throughout the body. People with ATTR amyloidosis may experience tendon weakness when abnormal TTR protein builds up in the tendons. About 1 in 3 people with ATTR can develop tendon-related issues, including tendon ruptures, which occur when the protein buildup makes tendons weaker.

Given your history of wrist and biceps tendon tears, it's possible that amyloid deposits could be affecting tendons in your leg as well. The nerve pain you're experiencing in your feet, shins, and calves is consistent with amyloidosis neuropathy. Nerve damage from amyloid protein buildup typically affects the feet and legs, causing:

* Numbness and tingling
* Pain in the feet and lower legs
* Weakness in feet and legs
* Difficulty walking
* Balance problems and increased fall risk
* Trouble with stairs

A MyAmyloidosisTeam member shared similar experiences: "The tingling in my fingers and feet is ongoing and definitely part of my neuropathy."

The combination of muscle weakness, nerve damage, and potential tendon involvement could all be contributing to your difficulty getting around and managing stairs. It's important to discuss these new symptoms with your doctor promptly. While Vyndamax can help slow disease progression, you may need additional evaluation to determine if your leg symptoms are related to amyloid progression or other factors. Your care team can help create a management plan that addresses both the tendon issues and neuropathy symptoms you're experiencing.

November 7, 2025
A MyAmyloidosisTeam Member

Jim, yes he does. I lost all my muscles in my arms/hands and legs. I have HATTR and now I'm on a wheelchair.

November 11, 2025
A MyAmyloidosisTeam Member

Jim has Wild cardiac Amyloidosis.

November 8, 2025
A MyAmyloidosisTeam Member

My husband has had neuropathy for at least 20 years so he has no feeling in his feet almost up to his knee. He also takes Vyndalink. He started with the Amvuttra in September and he feels not as tired and a little more energy. He is very hopeful that his health will keep improving. He also uses Voltaren, which helps.
I suggest getting on this nerve medication asap.

November 8, 2025

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